Learn About Uncontrolled Gout

The Kadence study is for adults with uncontrolled gout.

Uncontrolled gout occurs when uric acid levels remain high and gout symptoms keep coming back despite taking medication, leading to repeated flare-ups, ongoing joint pain, and sometimes hard lumps under the skin called tophi.

Can I Participate?

You may be eligible to participate in this study if you:   

Are 18 years of age or older   

Have uncontrolled
gout (symptoms continue despite current or prior treatment)

Have at least one of the following symptoms of uncontrolled gout:

2 or more gout flares in the past 12 months   

Chronic gouty arthritis (ongoing joint pain and swelling from gout)   

At least 1 tophus (lump caused by uric acid buildup) 

Have not been able to keep your uric acid levels in normal range using standard oral gout medications, or cannot take these medications

Other eligibility criteria apply and will be evaluated by a study doctor if you choose to continue with screening for the study. 

Check Your Eligibility

Unsure if your gout is considered uncontrolled?

You’re still welcome to apply, and you can review your gout diagnosis with your doctor to find out if it’s uncontrolled. 

What is the Purpose of the Kadence Study?  

This study is being conducted in adults with uncontrolled gout to evaluate the safety and efficacy of a study drug
administered as a subcutaneous injection compared to the study drug administered as an IV infusion. If approved, the subcutaneous administration of the study drug may offer a more convenient approach to managing uncontrolled gout.

I'm Interested

Why Should I Join the

Kadence

Study?

By enrolling in this study, eligible participants may receive:   

The study drug and placebo administered as an IV infusion or a subcutaneous injection under the skin at no cost.

Access to physicians with experience managing uncontrolled gout. 

Reasonable reimbursement for travel and parking.

All participants in the study will receive the study drug at no cost.

Learn More

What Should I Expect?

01
Submit Online Questionnaire
PatientWing is an organization helping to identify potential individuals who may be interested in the Kadence study. This questionnaire will ask for your contact information and answers to a few questions about your medical history to determine your eligibility. PatientWing will review the answers in your online questionnaire.

Then, select a time for a short phone call with PatientWing. Submitting the questionnaire is voluntary and does not require a commitment to participate in the study. 
02
Speak With PatientWing 
You will have a short call with PatientWing to answer additional questions about your medical history to determine potential initial eligibility.

PatientWing will review study details with you, and you’ll have the chance to ask questions and discuss any concerns.
03
Speak With a Research Site 
After your conversation with PatientWing, you will meet the research team who will review your medical records. 

If the research team thinks you are a good fit, they will schedule a screening visit to evaluate if you qualify for the study. 

You will be asked to review an Informed Consent Form (ICF) before any study-specific procedures take place. The ICF explains what the study is about, what participation involves, possible risks and benefits, and your rights as a participant. You will have time to ask questions before deciding whether to sign it. Signing the ICF means you agree to take part in the screening process for the study.

The research team will provide more information during your conversations with them. No question is a bad question so please share your concerns with the team!
04
Study Participation
After you've completed the screening period, the research team will notify you about your eligibility. 

If eligible, you’ll complete a 4-week run-in period using methotrexate. If you tolerate it well, you’ll move into a 48-week treatment period that includes the study drug along with methotrexate and regular study visits. You’ll also have follow-up visits so the study team can monitor your progress.

Participation in this study will not come at an additional cost to you. Reasonable reimbursement for travel and parking may be provided to eligible study participants. 
Fill Out The Questionnaire

Frequently Asked Questions

How do I get started?

Fill out the questionnaire and provide basic information to express interest in the study. You can also email studies@patientwing.com or call 213-459-2979. 

How is PatientWing involved in this clinical study process?  

We partner with study sponsors to match individuals with clinical studies. Our dedicated team provides clear information about available studies, connects you with research sites, and ensures you have the resources and guidance you need at every step. We are here to support your journey with clinical research!

What is the duration of thestudy?

If you are eligible to participate in the Kadence study, your participation may last about 15 months. 

Is there a chance I will receive a placebo? 

All participantsin this study will receive the study drug, along with a placebo delivered as an IV infusion or a subcutaneous injection. A placebo does not contain any active medicine. This helps determine whether changes in a participant’s condition are due to the study drug or occur by chance or are due to other factors. The subcutaneous administration of the study drug is being tested to see if it can potentially help to manage uncontrolled gout.

Can I leave the study at any time? 

Yes. You may stop taking the study drug while continuing all other tests, procedures, and follow-upvisits as part of the study, or you may leave the study but remain in contact with the study team for follow-up. You can also choose to have no further contact with the study team. If you stop participatingin the study, or if the study ends early, you will no longer receive the study drug.

How often do I need to visit the research site?  

You will have visits approximately every 2weeks for 48weeks. There are about 31 total visits in person, including a final safety follow-up visit.

Are there possible benefits of participating?

Taking part in this study may or may not help to treat your gout symptoms. Your health could improve, stay the same, or get worse. However, the data we get from you during this study may help doctors learn more about the subcutaneous administration of the study drug and whether it is safe and effective for adult patients diagnosed with uncontrolled gout. 

How many participants will be involved in this study?

Approximately 270 adults diagnosed with uncontrolled gout will be involved in the Kadence study across the USA.

Can I choose the delivery method of the study drug?

No. You will be randomly assigned to one of two groups and will receive both the study drug and a placebo. The study drug will be given either as a subcutaneous injectionoran IV infusion, and the placebo will be given using the other method. You will have an equal chance of being placed in either group.

About PatientWing

Our mission to bring better treatments to more people faster starts with you. We help sponsors find patients to participate in their clinical studies. With our focus on rare and serious conditions and expertise in navigating the enrollment process, we're here for patients every step of the way. 

Contact  PatientWing  

If you have a patient who may be eligible, we would love to speak with you! Please submit the information below so our team can reach out. There is no obligation to you or your patient, by submitting this form.   

Contact Us

studies@patientwing.com

213-459-2979

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